For new designs, the Cmedia CM6533 is highly reomended. The CM6533 integrates FLASH and Xtal which reduces BOM cost.
CM6500B is a USB 2.0 audio chip builds in 8051 for flexible applications. With internal 2-channel ADC and DAC and S/PDIF interface makes it suits for Headset, Docking, Speaker and Mic applications. The internal 8051 can be also developed to a lot of different applications, such as Lync device, iDevice docking or even Android Phone or Tablet/Slate docking device.